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Market Overview:

The Global Oligonucleotide Synthesis market is expected to offer an $ opportunity of USD 15,502.90 Million over the forecast period.

The Oligonucleotide Synthesis market size is expected to surge from USD 5,821.9 Million in base year i.e. 2022 to USD 21,324.8 Million by analysis period 2035, and registering compound annual growth rate (CAGR) of approximately 10.31% over the forecast period 2023 and 2035. 

Global Market Size, Forecast, and Trend Over Analysis Period 2022 - 2035

Base Year2022
Forecast Year2023-2035
CAGR10.31%
Base Year Market Size (2022)USD 5,821.9 Million
Forecast Year Market Size (2035)USD 21,324.8 Million

Oligonucleotides are primarily employed in biological and forensic applications in research, disease diagnosis, and therapeutics among others. Natural oligonucleotides have been extensively used for the segregation and selection of the DNA sequences such as hybridization probes or affinity purification, gene construction, and site-directed mutagenesis. Furthermore, they are used to hamper gene expression in in-vitro studies for diagnostic purposes.

Depending on the application criteria oligonucleotide produced at customized level, they distantly differ in the features and quality aspects

Uncover the Role of Technologies Oligonucleotide Productions:

Extensive utilization of oligonucleotides has facilitated the need for technological developments in synthetic chemistry. A large number of biotechnology and pharmaceutical companies are therefore engaged in the development of newer and advanced methods. For instance, Integrated DNA Technologies has developed oligonucleotides up to 200 base lengths which are used with mass spectrometry for manufacturing mini-genes. 

Application Assessment Insights: 

Report has investigated the how Oligonucleotides used in several application such Research, Diagnostic, Forensic and Therapeutic and opportunity lies in these segments

Market Enablers:

Significant endorsement by government for synthetic biology and genome projects.

Market Challenges:

The market for oligonucleotide synthesis may be hamper by the complication associated with therapeutic oligos and challenging delivery of oligonucleotide drugs to a particular target. However, growth opportunities in emerging economies are on rise.

Regional Market Outlook: 

Global market has been segregated into five regions such as North America, Europe, Asia Pacific, Latin America and Middle East and Africa. North America is currently occupied the larger share and it was estimated around 38.7% in the base year. This is mainly attributed due to the presence of large number of market players accompanied with tremendous R&D activities in the region. As United States is the leading market in terms of higher R&D expenditure. Asia-Pacific is another lucrative market offering numerous opportunities. Player in the region such Bio Basic Asia Pacific Pte Ltd. has been consistently synthesizing oligonucleotides (non-modified oligo & modified oligo) for a variety of research applications for over 15 years.

Strategic Developments in the Market:

  • Aurisco in collaboration with Cytiva announced to establish Oligonucleotides Manufacturing Facility in China. Annual production expected to be around 200 kilograms
  • Another firm WuXi STA, a subsidiary of WuXi AppTec, revealed the development of a new large-scale oligonucleotide and peptide manufacturing facility at its Changzhou campus

Market Segmentation:

Our in-depth analysis of the global Oligonucleotide Synthesis market includes the following segments:

Global Oligonucleotide Synthesis Market
Base Year:2022Forecast Period:2024-2035
Historical Data:2020 to 2022Market Size in 2022:USD 5,821.9 Million
Forecast Period 2024-35 CAGR:10.31%Market Size in 2035:USD 21,324.8 Million
Segments Covered:By Product
  • Oligonucleotide Synthesis Reagents & Consumables
  • Oligonucleotide Synthesis Equipment
  • Synthesized Oligonucleotides
    • DNA Oligonucleotides
    • RNA Oligonucleotides
  • Other Oligonucleotide Synthesis Products
By Application
  • Research
    • Polymerase Chain Reaction (PCR)
    • Next-Generation Sequencing
    • Others
  • Therapeutics
    • Antisense Oligonucleotides
    • Nucleic Acid Aptamers
  • Diagnostics
By End User
  • Biotechnology & Pharmaceutical Companies
  • Research Institutes
  • Diagnostic Laboratories
By Region
  • North America (U.S., Canada)
  • Europe (United Kingdom, Germany, France, Italy, Spain, Russia, Rest of Europe)
  • Asia-Pacific (China, India, Japan, South Korea, Singapore, Australia, New Zealand, Rest of APAC)
  • Middle East & Africa (Saudi Arabia, Israel, UAE, South Africa, Rest of MEA)
  • South America (Brazil, Mexico, Argentina, Rest of South America)
Key Market Drivers:
  • Increased usage of oligonucleotides has augmented the need for technological advancements
  • Surging demand for novel treatment options
Key Market Restraints:
  • Production cost, regulatory benchmark
Key Opportunities:
  • Growing demand in institution
  • Fulfilling market unmet need
Companies Covered in the Report:
  • Syngene International Limited
  • Thermo Fisher Scientific Corporation
  • TCI Chemicals
  • Bachem
  • GenScript Biotech Corporation
  • Integrated DNA Technologies Inc.
  • Sigma-Aldrich Corporation
  • WuXi STA
  • GE Healthcare
  • Kaneka Eurogentec S.A.
  • TriLink Biotechnologies LLC
  • BioAutomation
  • ATDBio Ltd. 
  • Other Major Players